Beilstein J. Org. Chem.2019,15, 2380–2389, doi:10.3762/bjoc.15.230
photoswitchable imaging of intracellular glutathione (GSH). The photochromicglycosheet manifests significantly turn-on fluorescence and dynamic ON/OFF fluorescence signals in response to GSH, which makes it favorable for intracellular GSH double-check in targeted human hepatoma cell line (HepG2) through the
therapy.
Keywords: intracellular GSH; molecular switches; photochromicglycosheet; photoswitchable imaging; 2D MnO2 nanosheets; Introduction
Cells are the basic structure and functional unit of biological organisms. Human diseases and aging are closely related to the states of cells. Thorough
nanosheets. This result reveals that the photochromicglycosheet is capable of recognizing GSH, leading to a significant turn-on of the quenched fluorescence. The photoswitchable fluorescence signal was also activated alongside the recovery of naphthalimide emission. As shown in Figure 3C, the fluorescence
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Graphical Abstract
Scheme 1:
The structure (A) of reporter Glyco-DTE and working principle (B) of photochromic glycosheet Glyco-...